11β-hydroxysteroid dehydrogenase inhibitors

Details 11β-hydroxysteroid dehydrogenase inhibitors 11β-hydroxysteroid dehydrogenase inhibitors

2007-06-12

2007-06-12

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S375000, C548S170000, C548S217000

Reexamination Certificate

active

10970064

ABSTRACT:
A compound having Formula Iin-line-formulae description="In-line Formulae" end="lead"?R1—Z—R2Formula Iin-line-formulae description="In-line Formulae" end="tail"?wherein R1is an optionally substituted phenyl ring; R2is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L— wherein either X is selected from —S(═O)(═O)— and —C(═O)—; and Y is —NR3—; or X is selected from —S(═O)(═O)— and —S—, and Y is —C(R4)(R5)—; L is an optional linker; and R3, R4and R5are each independently selected from H and hydrocarbyl; and wherein when R2comprises the following structural moietywherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1—C(═O)—NR3—L—R2; R1—S(═O)(═O)—C(R4)(R5)—L—R2; R1—S—C(R4)(R5)—L—R2; R1—NR3—S(═O)(═O)—L—R2; R1—NR3—C(═O)—L—R2; R1—C(R4)(R5)—S(═O)(═O)—L—R2; and R1—C(R4)(R5)—S—L—R2.

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