Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-11
2009-11-03
Desai, Rita J (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S450000
Reexamination Certificate
active
07612219
ABSTRACT:
Process for the preparation of olopatadine (I), which comprises reacting a compound of formula (V) in the presence of a palladium catalyst to provide a compound of formula (VI), wherein the acid protecting group is removed to provide the compound of formula (I) and if desired, transformation into its salts.
REFERENCES:
patent: 4871865 (1989-10-01), Lever, Jr. et al.
patent: 5116863 (1992-05-01), Oshima et al.
patent: 6638977 (2003-10-01), Madison et al.
Etsuo, Otaki et. al. “Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives.” Journal of Medicinal Chemistry, 1992 35(11), 2074-84.
Soederberg, Bjoern et. al. “Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation.” Tetrahedron, 2005, 61(15), 3637-3649.
Denieul, Marie-Pierre et. al. “Synthesis of the Benzophenone Fragment of Balanol via an Intramolecular Cyclization Event.” Journal of Organic Chemistry, 2000, 65(19), 6052-6060.
Finch, Harry, et al., “The Synthesis of a Conformationally Restrained, Combined Thromboxane Antagonist/Synthase Inhibitor Using an Intramolecular ‘Stille’-or ‘Grigg’-Palladium-Catalysed Cyclisation Strategy,” Tetrahedron Letters, 34(51): 8353-8356 (1993).
Chaudhuri, Gopeswar et al., “A highly regio- and stereoselective synthesis of (Z)-3-arylidene-2,3-dihydro-5H-1,4- benzodioxepin-5-ones and (Z)-3-arylidene-1,2,3,5-tetrahydro-4,1-benzoxazepin-5-ones through palladium-copper catalysis,” J. Chem. Soc. Perkin Trans. 1: 775-779 (2000).
Alonso Marin Yolanda
Bachs Roca Jordi
Bessa Sanchez Mercè
Bosch Cartés Joan
Gomez Gomez Antonia Ma
Desai Rita J
O'Dell David K
Rothwell Figg Ernst & Manbeck
Urquima S.A.
LandOfFree
11—[ (Z) -3- (dimethylamino) propylidene]—6,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 11—[ (Z) -3- (dimethylamino) propylidene]—6,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 11—[ (Z) -3- (dimethylamino) propylidene]—6,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4091935