Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-11-07
1986-08-26
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
546208, 548518, 540547, A61K 3140, C07D49804, C07D40106, C07D40306
Patent
active
046083740
ABSTRACT:
There are described to novel 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines of the general formula ##STR1## where m and n are each independently 0, 1 or 2 and m+n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen, and R is hydrogen, cyano, --C(NH.sub.2)NOH, ##STR2## unsubstituted loweralkyl, or substituted loweralkyl having one to three substituents each of which being independently cyano, hydroxy, cyclohexyl, furyl, thienyl, ##STR3## k being 1, 2 or 3, W being each independently hydrogen, halogen, hydroxy, loweralkyl, trifluoromethyl, loweralkoxy, nitro, amino, diloweralkylamino, phenoxy, or benzyloxy, and Z being hydrogen, loweralkyl or halogen, which are useful as antipsychotic and analgesic agents; novel intermediate compounds therefor; and methods of synthesizing the foregoing compounds.
REFERENCES:
patent: 4029672 (1977-06-01), Effland et al.
patent: 4045448 (1977-08-01), Effland et al.
patent: 4053599 (1977-10-01), Effland et al.
patent: 4107074 (1978-08-01), Effland et al.
patent: 4107187 (1978-08-01), Effland et al.
patent: 4169094 (1979-09-01), Effland et al.
patent: 4169095 (1979-09-01), Effland et al.
patent: 4263438 (1981-04-01), Althuis et al.
Burger, ed., Medicinal Chemistry, 3rd ed., pt. II, Wiley-Interscience, (1970) pp. 1410-1411.
Davis Larry
Effland Richard C.
Kapples Kevin J.
Daus Donald G.
Hoechst-Roussel Pharmaceuticals Inc.
Ikeda Tatsuya
Teoli, Jr. William A.
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