11-methylene-oestr-15-enes, processes for their preparation, and

Details 11-methylene-oestr-15-enes, processes for their preparation, and 11-methylene-oestr-15-enes, processes for their preparation, and

1991-04-01

1993-08-17

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 552526, A61K 3156, C07J 700

Patent

active

052369137

ABSTRACT:
The present invention is concerned with novel 11-methylene-oestr-15-enes of the formula: ##STR1## wherein R.sub.1 =H or acyl with 1-18 C-atoms, preferably H,

REFERENCES:
patent: 3927046 (1975-12-01), van den Broek
Ralph I. Dorfman, "Androgens and anabolic agents. In Dorfman R. I.", Methods in Hormone Research, vol. II, Bioassay, Academic Press. Cover page. (1962).
C. W. Emmens, "Estrogens. In: Dorfman R. I." (ed) Methods in Hormone Research, vol. II, Bioassay, Academic Press. Page 65. (1962).
T. Miyake, "Progestational Substances In: Dorfman R. I." (ed) Methods in Hormone Research, vol. II, Bioassay. Academic Press, p. 135 (1962).
R. I. Dorfman, "Androgens and anabolic agents." In: Dorfman R. I. (ed), Methods in Hormone Research, vol. II Bioassay, Academic Press, pp. 304-305 (1962).
David J. Finney, "Assays based on quantal responses." In: Statistical method in biological assay. Third Edition. Charles Griffin & Company Ltd., p. 370.
A. J. van den Broeck, et al., "11-Aklylidene steroids in the 19-nor series", Recueil, Journal of the Royal Netherlands Chemical Society, vol. 94, No. 2, Feb. 1975, pp. 35-39.
L. Wiinikka et al., "Metabolism of a New Synthetic Progestagen, Org 2969, in Female Volunteers. Pharmacokinetics after an Oral Dose", European Journal of Clinical Pharmacology, vol. 15, pp. 349-355 (1979).
Lasse Viinikka, "Metabolism of a New Synthetic Progestagen, Org 2969, By Human Liver in Vitro", Journal of Steroid Biochemistry, vol. 10, pp. 353 to 357, (1979).

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