11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl

Details 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl

1978-11-30

1980-06-17

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, 546 74, C07D22126

Patent

active

042085233

ABSTRACT:
3-R.sub.1 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 "'-11(ax)-R.sub.3 -6(eq)-R.sub.4 -11(eq)-(CH.sub.2 CH.sub.2 CH.sub.2 R.sub.5)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, generally useful as morphine-like analgesics and as narcotic antagonists, are prepared by reducing, under Wolff-Kishner reaction conditions, a corresponding 3-R.sub.1 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 "'-11(ax)-R.sub.3 -6(eq)-R.sub.4 -11(eq)-(CH.sub.2 CH.sub.2 COR.sub.5)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and, if desired, cleaving a lower-alkoxy, methoxymethoxy or benzyloxy group to an hydroxy group.

REFERENCES:
patent: 3733330 (1973-05-01), Schubert et al.
patent: 3764606 (1973-10-01), Akkerman et al.
patent: 3969468 (1976-07-01), Tamaki et al.
patent: 3981874 (1976-09-01), Merz et al.
patent: 4020164 (1977-04-01), Rahtz et al.
patent: 4128548 (1978-12-01), Akkerman et al.
Ager, J., et al., J. Med. Chem., 6, 322-325, (1963).
Rice, K., et al., J. Med. Chem., 18, 854-857, (1975).
Fieser, L., et al., Reagents for Organic Synthesis, John Wiley, New York, 1967, p. 435.
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 319-320.

Affiliated with

Also associated with

Rating

11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-475953