11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5

Details 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5

1989-11-01

1991-08-20

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514179, 514182, 540108, 540110, 552531, 552532, 552544, 552552, 552555, 552603, 552611, 552643, A61K 3158, A61K 3156, C07J 4300, C07J 4100, C07J 1300, C07J 100, C07J 3100

Patent

active

050414330

ABSTRACT:
Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase.

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patent: 4377584 (1983-03-01), Rasmusson et al.
patent: 4814324 (1989-03-01), Borris et al.
patent: 4910226 (1990-03-01), Holt et al.
Hsia and Voight, J. Invest. Dermat. 62:224-227 (1974).
Robaire et al., J. Steroid Biochem. 8:307-310 (1977).
Blohm, T. R., et al., Biochem. Biophys. Res. Comm. 95:273-280 (1980).
Liang, T., et al., J. Steroid Biochm. 19:385-390 (1983).
Petrow, V., et al., Steroids 38:121-140 (1981).
Brookds et al., Steroids: 47:1-19 (Jan. 1986).

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