11-Deoxy-cis-13-PGE.sub.2 analogs

Details 11-Deoxy-cis-13-PGE.sub.2 analogs 11-Deoxy-cis-13-PGE.sub.2 analogs

1977-03-03

1978-10-10

Gersil, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562503, C07C17700

Patent

active

041197879

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is of the cis configuration. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3914282 (1975-10-01), Pike
patent: 3932463 (1976-01-01), Schaub et al.
patent: 3933889 (1976-01-01), Maglerlin
patent: 3933899 (1976-01-01), Nelson
patent: 3959346 (1976-05-01), Schneider
patent: 3962293 (1976-06-01), Magerlin
patent: 3970685 (1976-07-01), Untch et al.
Burger, Medicinal Chemistry, p. 81.2 (1960).

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