11-Deoxy-11.alpha.-alkyl-PGE compounds from PGA compounds by lit

Details 11-Deoxy-11.alpha.-alkyl-PGE compounds from PGA compounds by lit 11-Deoxy-11.alpha.-alkyl-PGE compounds from PGA compounds by lit

1982-06-23

1984-10-16

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

549 78, 549498, 560121, 562503, 568330, 424305, 424317, 424331, C07C17700

Patent

active

044776845

ABSTRACT:
The present invention provides a process for the preparation of 11.alpha.-alkylprostaglandin E compounds from corresponding prostaglandin A compounds via reaction with alkyllithium complexes, and novel 11-deoxy-11.alpha.-alkylprostaglandin E compounds useful for the same pharmacological purposes as the natural PGE compounds, e.g., antiulcer and antisecretory effects.

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