11 .beta.-substituted progesterone analogs

Details 11 .beta.-substituted progesterone analogs 11 .beta.-substituted progesterone analogs

1990-04-03

1991-12-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514179, 552520, 552603, 552605, 552608, 552514, C07J 1700, A61K 3158

Patent

active

050735489

ABSTRACT:
A 11.beta.-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, OH, OC(O)CH.sub.3, or OC(O)R.sup.5 , wherein R.sup.5 is C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl or aryl, R.sub.2 is H, R.sup.3 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, R.sup.4 is H, CH.sub.3, F or Cl, R.sup.6 is H, (CH.sub.3).sub.2 N, CH.sub.3 O, CH.sub.3 CO, CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, and X is O or NOCH.sub.3 ; or

REFERENCES:
patent: 4386085 (1983-05-01), Teutsch et al.
patent: 4477445 (1984-10-01), Philibert et al.
patent: 4540686 (1985-09-01), Philibert et al.
Neef et al., Chemical Abstracts vol. 104, 1986 Abstract 34230f.

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