11 .beta.-substituted progesterone analogs

Details 11 .beta.-substituted progesterone analogs 11 .beta.-substituted progesterone analogs

1988-06-23

1990-09-04

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514179, 514192, 514177, 514169, 552529, 552597, 552598, 552604, 552558, 552608, 552531, 552520, 552596, 552605, 552514, 552592, 552628, 552532, 540 54, 540 36, 540 37, A61K 3156, C07J 100

Patent

active

049544900

ABSTRACT:
A 11.beta.-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, OH, OC(O)CH.sub.3, or OC(O)R.sup.5, wherein R.sup.5 is C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl or aryl, R.sub.2 is H, R.sup.3 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, R.sup.4 is H, CH.sub.3, F or Cl, R.sup.6 is H, (CH.sub.3).sub.2 N, CH.sub.3 O, CH.sub.3 CO, CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, and X is O or NOCH.sub.3 ; or

REFERENCES:
Chemical Abstracts; vol. 100 (1984); #68601k; Philibert et al.
Chemical Abstracts; vol. 108 (1988); #6285s; Philibert et al.

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