Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-02-20
2007-02-20
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S383000, C540S476000, C548S269400
Reexamination Certificate
active
10697547
ABSTRACT:
Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof:are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidernia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.
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Reimlinger et al., Chemische Berichte, vol. 103, No. 6, pp. 1960-1981 (1970), “Synthesis of s-triazolo[3,4-a]isoquinolines” (full text).
Balkovec James M.
Olson Steven H.
Zhu Yuping
Billups Richard C.
Merck & Co. , Inc.
Saeed Kamal A.
Winokur Melvin
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