11.alpha.-METHYLSUBSTITUTED PROSTAGLANDIN DERIVATIVES

Details 11.alpha.-METHYLSUBSTITUTED PROSTAGLANDIN DERIVATIVES 11.alpha.-METHYLSUBSTITUTED PROSTAGLANDIN DERIVATIVES

1974-05-10

1976-01-27

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260349, 260488R, 260514D, 424305, 424317, C07C14702, C07C14714, C07C14926

Patent

active

039352412

ABSTRACT:
Novel 8R-antimeric and racemic 11.alpha.-methylsubstituted-prosta-5-cis, 13-trans-dienoic and prost-13-trans-enoic acids having oxygenated functions at the C-9 and C-15 positions of the molecule, as well as the 15-methyl or ethyl derivatives thereof and processes for making such compounds. Also encompassed are the pharmaceutically acceptable, non-toxic alkyl esters and salts of the carboxylic acid function of these novel compounds.

REFERENCES:
patent: 3845042 (1974-10-01), Stnk et al.
Fieser et al., Reagents, For Organic Synthesis, p. 810, 1247, 1248, (1967).
Fieser et al., Reagents for Organic Synthesis, Vol. 3, p. 36, (1972).
Wygand et al., Preparative organic Chemistry, p. 638, (1971).

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