11.alpha.-Hydroxymethyl prostaglandins

Details 11.alpha.-Hydroxymethyl prostaglandins 11.alpha.-Hydroxymethyl prostaglandins

1974-02-21

1976-01-06

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029305, 2603458, 260445R, 2604458R, 260488R, 2605011, 26050111, 26050117, 260514D, 424305, 424317, C07C 6138, C07C 6974

Patent

active

039312828

ABSTRACT:
Novel process for the preparation of 11.alpha.-hydroxymethyl derivatives of natural (8R-) and racemic 9-keto-15.alpha.-hydroxy- and 9,15.alpha.-dihydroxy-prosta-5-cis,13-trans-dienoic and prost-13-transenoic acids, and the novel 15-methyl and ethyl substituted derivatives thereof, as well as the esters of the primary and secondary hydroxy groups and the non-toxic, pharmaceutically acceptable salts of the novel compounds.

REFERENCES:
patent: 3845042 (1974-10-01), Strike et al.

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