Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1979-05-04
1980-07-22
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424267, 546 74, C07D40506
Patent
active
042140854
ABSTRACT:
3-R.sub.1 -6(eq)-R.sub.4 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 '''-11(ax)-R.sub.3 -11(eq)-[CH.sub.2 CH.sub.2 CO(CH.sub.2).sub.n -(2- and 3-furyl)]-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, useful as analgesics and narcotic antagonists, are prepared either by heating, with formic acid in an organic solvent or with certain ammonium formates, certain lower-alkyl 1-R.sub.1 -4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 "-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 '''-3-[CO(CH.sub.2).sub.n -(2- and 3-furyl]-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3-carb oxylates or by reaction of a lower-alkyl .beta.-[3-R.sub.1 -6(eq)-R.sub.4 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 '''-11(ax)-R.sub.3 -1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionate with 2- or 3-furylacetic acid in the presence of a strong base.
REFERENCES:
patent: 3250678 (1966-05-01), Archer
patent: 3733330 (1973-05-01), Schubert et al.
patent: 3776914 (1973-12-01), Atsumi
patent: 3932422 (1976-01-01), Michne
Lewis Thomas R.
Michne William F.
Ford John M.
Schwartz Richard A.
Sterling Drug Inc.
Webb W. G.
Wyatt B. W.
LandOfFree
11-[3-Oxo-.omega.-(2- and 3-furyl)-lower-alkyl]hexahydro-2,6-met does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 11-[3-Oxo-.omega.-(2- and 3-furyl)-lower-alkyl]hexahydro-2,6-met, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 11-[3-Oxo-.omega.-(2- and 3-furyl)-lower-alkyl]hexahydro-2,6-met will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2179142