11,15-Dihydroxy-9-oxoprost-13-ynoic acid

Details 11,15-Dihydroxy-9-oxoprost-13-ynoic acid 11,15-Dihydroxy-9-oxoprost-13-ynoic acid

1974-11-12

1976-07-20

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 2603451, 2603457, 2603458, 2603459, 260429R, 2604381, 260448R, 2604488R, 260468R, 260488R, 260488H, 260514D, 260514R, 2606065B, 424305, 424317, C07L 6138, C07L 6974

Patent

active

039706834

ABSTRACT:
3-(Optionally oxygenated)-5-oxocyclopent-1-enealkanoic acids and their alkyl esters are allowed to react with appropriate alkenyl copper, alkenyl boron, alkynyl boron, alkynyl gallium or alkynyl aluminum compounds to produce the corresponding 2-(3-hydroxy-3-[optionally alkylated]-1-alkenyl)cyclopentanealkanoic acids, 2-(3-hydroxy-3-[optionally alkylated]-1-alkynyl)cyclopentanealkanoic acids and their esters. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their central nervous system-affective, anti-bacterial, anti-fungal and prostaglandin antagonist activity.

REFERENCES:
pappo et al., Prostaglandins, Annals of N.Y. Acad. of Sci. 180, 64 (1971).

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