11,12-Difluoromethylene substituted prostanoic and prost-5-cis-e

Details 11,12-Difluoromethylene substituted prostanoic and prost-5-cis-e 11,12-Difluoromethylene substituted prostanoic and prost-5-cis-e

1975-06-23

1977-01-04

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 2603409, 2603433R, 2603462M, 26050116, 26050117, 260514D, 424305, 424317, C07C17700

Patent

active

040012956

ABSTRACT:
Novel racemic and antimeric prostaglandin analogs having a difluoromethylene group attached to the C-11,12 positions of the molecule, and oxygenated functions at C-9 and C-15, which may be further substituted at C-15 by a methyl group and processes for the production of such compounds. Also included are the lower alkyl esters of the carboxylic acid function and pharmaceutically acceptable salts thereof. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals, where prostaglandins are indicated.

REFERENCES:
patent: 3725454 (1973-04-01), Beal
patent: 3867423 (1975-02-01), Crabbe

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