Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-07-11
1991-04-02
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 530381, 530395, 530412, 530413, 530417, 530421, 530829, 435217, 435215, 435212, 435216, 514 2, 514 8, 514 21, A61K 3702, C07K 1506, C07K 1514
Patent
active
050048023
ABSTRACT:
A protein called PA binding protein has been isolated which binds specifically and reversibly to tissue plasminogen activator. The protein is characterized by a molecular mass of about 100,000 daltons, and electrophoretic mobility in agarose at pH 8.6 equal to that of plasma .beta.-globulins and an isoelectric point of 6.5 to 7.0. The protein is thermostable up to at least 56.degree. C. and is cleared from the circulation with a half life on the order of days.
REFERENCES:
Chemical Abstracts, vol. 94, No. 1, May 25, 1981, p. 431, Abstract No. 171576n, Takashi Okamura.
Chemical Abstracts, vol. 70, No. 15, Apr. 14, 1969, pp. 157-158, Abstract No. 66029t, G. J. H. Den Ottolander et al.
Chemical Abstracts, vol. 92, No. 5, Feb. 4, 1980, p. 337, Abstract No. 36736h, L. B. Nanninga et al.
Chemical Abstract, vol. 101, No. 19, Nov. 5, 1984, p. 424, Abstract No. 167884g, E. D. Sprengers et al.
Proc. Natl. Acad. Sci. U.S.A., vol. 80, May 1983, pp. 2956-2960, D. J. Loskutoff et al., Cell Biology.
Chemical Abstracts, vol. 98, No. 9, Feb. 28, 1983, p. 405, Abstract No. 69433j, J. J. Emeis et al.
Kepplinger Esther L.
Kushan Jeff P.
Nederlandse Centrale Organisatie voor Teegepast-Natturwentenscha
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