10-(Piperidin o-alkyl)-phenothiazines

Details 10-(Piperidin o-alkyl)-phenothiazines 10-(Piperidin o-alkyl)-phenothiazines

1975-03-25

1977-04-19

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243A, 26029366, 26029382, 26029384, 26029388, 2602939, A61K 31445, A61K 3154

Patent

active

040189228

ABSTRACT:
Novel 10-(piperidino-alkyl)-phenothiazines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, --CF.sub.3, --OCH.sub.3 and SCH.sub.3, B and R are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z' is selected from the group consisting of hydrogen and alkyl of 1 to 10 carbon atoms, p is 0 or 1, n is 0, 1 or 2 and A is selected from the group consisting of hydrogen, --COOR.sub.2 and --COR.sub.1, R.sub.2 is linear alkyl of 1 to 15 carbon atoms and R.sub.1 is selected from the group consisting of alkyl of 1 to 18 carbon atoms optionally containing a double bond or --O-- and a polymethoxyphenyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, analgesic, spasmolytic and antihistaminic activity and their preparation and novel intermediates.

REFERENCES:
patent: 3126379 (1964-03-01), Davis
patent: 3140284 (1964-07-01), Habicht et al.
patent: 3193549 (1965-07-01), Zenitz
patent: 3305547 (1967-02-01), Stach et al.
patent: 3891636 (1975-06-01), Derible et al.
Schenker-Herbst, Progress in Drug Research, vol. 5, frontispage and pp. 269, 304 to 307 and 419 to 426, Birkhauser Verlag Basel and Stuttgart (1963).

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