10'-( .omega.-N)-1,4-Diazabicyclo(4,3,0)-alkanyl-lacyl) -phenoth

Details 10'-( .omega.-N)-1,4-Diazabicyclo(4,3,0)-alkanyl-lacyl) -phenoth 10'-( .omega.-N)-1,4-Diazabicyclo(4,3,0)-alkanyl-lacyl) -phenoth

1976-09-24

1978-04-11

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 3154

Patent

active

040839761

ABSTRACT:
Novel compounds 10'-[.omega.-N/1,4-diazabicyclo(4,m,0)-alkanyl/-acyl] -phenothiazines having the formula: ##STR1## wherein X = H, Cl, CF.sub.3 ; n = 1, 2, 3; m = 3, 5; and their salts of acidic addition and quaternary salts. The process for producing said compounds comprises reacting .omega. -chloracyl -2-substituted phenothiazines with 1,4-diazabicyclo(4,m,0)-alkanes in an inert solvent medium at a temperature of 50-140.degree. C followed by isolation of the desired product.
Said compounds are pharmacologically active. The most active compound 10'- [.beta.-N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propyonyl]-2'-chlorophenothia zine of the formula: ##STR2## is an active principle of a medicated compound possessing spasmolytic and coronary-dilatant effect.

REFERENCES:
patent: 2591679 (1952-04-01), Cusic
patent: 2694705 (1954-11-01), Cusic
patent: 3055891 (1962-09-01), Cusic
patent: 3320246 (1967-05-01), Cusic et al.

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