10-Hydroxy PGC compounds

Details 10-Hydroxy PGC compounds 10-Hydroxy PGC compounds

1972-09-08

1976-01-06

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 2602436S, 2603457, 2603458, 2603405, 2603433, 2603473, 2603474, 260410, 260448R, 260468R, 260468D, 2604686, 260464, 260473G, 260476R, 260484R, 260485L, 260486R, 260487, 260488R, 2605011, 26050111, 26050117, 424305, 424317, C07C 6138, C07C 6474

Patent

active

039312976

ABSTRACT:
10.alpha.-Hydroxy-11-desoxy-prostaglandin analogs of the PGE.sub.1 and PGE.sub.2 and PGF.sub.1.sub..alpha. and PGF.sub.2.sub..alpha. series, the 11-dehydro derivatives thereof as well as the 9,10-ketals in the PGF series, and methods of preparing same, 9-keto-10.alpha.,15.alpha.-dihydroxyprosta-13-trans-enoic or 5-cis,13-trans-dienoic acid, 9.alpha.,10.alpha.,15.alpha.-trihydroxyprosta-11,13-trans-dienoic or 5-cis, 11,13-trans-trienoic acid and 9.alpha.,10.alpha.-isopropyli-denedioxy-15.alpha.-hydroxyprosta-13-trans-e noic or 5-cis,13-trans-dienoic acid are representative of the class. Also included are the corresponding pharmaceutically acceptable, non-toxic esters, ethers and salts. These compounds possess prostaglandin-like activity and thus are useful in the treatment of mammals, where prostaglandins are indicated.

REFERENCES:
patent: 3846475 (1974-11-01), Crabbe et al.

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