10-halo-E-homoeburnane derivatives, a process for the preparatio

Details 10-halo-E-homoeburnane derivatives, a process for the preparatio 10-halo-E-homoeburnane derivatives, a process for the preparatio

1980-08-05

1981-08-25

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, 2602457, 546 70, C07D47122, A61K 31395

Patent

active

042859506

ABSTRACT:
The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), ##STR1## wherein R.sup.2 is a C.sub.1-6 alkyl group and X is halogen, and epimers, optically active derivatives and pharmaceutically acceptable acid addition salts thereof. These substances exert vasodilating effects and can be applied to advantage in the therapy.
The new compounds are prepared so that a racemic or optically active 9-halo-octahydroindoloquinolisine derivative of the general formula (II), ##STR2## wherein R.sup.2 and X are as defined above and R.sup.1 is a C.sub.1-6 alkyl group, or an acid addition salt thereof is treated with a strong base, and, if desired, the 15-epimers of the resulting compound having the general formula (I) are separated from each other, and/or, if desired, the resulting substance is converted into its pharmaceutically acceptable acid addition salt and/or resolved.

REFERENCES:
patent: 3770724 (1973-11-01), Warnant et al.

Affiliated with

Also associated with

Rating

10-halo-E-homoeburnane derivatives, a process for the preparatio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 10-halo-E-homoeburnane derivatives, a process for the preparatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 10-halo-E-homoeburnane derivatives, a process for the preparatio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1158506