10'desmethoxystreptonigrin production by Streptomyces albus

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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4352535, 435887, C12P 1712, C12N 120

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active

053209559

ABSTRACT:
10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.

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Okada et al., Biological Properties of Streptonigrin Derivatives II. Inhibition of Reverse Transciptase Activity; The Journal of Antibiotics, vol. XXXIX, No. 2, pp. 306-308 (1986).
Shaikh et al., Streptonigrin. 1. Structure-Activity Relationships among Simple Bicyclic Analogues. Rate Dependence of DNA Degradation on Quinone Reduction Potential; J. Med. Chem., 29, pp. 1329-1340 (1986).
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