Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-03-29
1991-07-09
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514825, A61K 31495, A61K 3150
Patent
active
050306340
ABSTRACT:
A double blind clinical trial of 10-deazaaminopterin versus the antirheumatoid drug methotrexate (MTX) established that 10-deazaaminopterin, in addition to being at least equally effective as methotrexate in all respects in ameliorating rheumatoid arthritis in humans, it is superior to methotrexate in controlling pain and joint stiffness and in improving grip strength. In accordance with this invention 10-deazaaminopterin is claimed as a more effective disease modifying arthritis remittive drug for the treatment of rheumatoid arthritis in humans.
REFERENCES:
patent: 4369319 (1983-01-01), DeGraw, Jr. et al.
patent: 4393064 (1983-07-01), DeGraw, Jr. et al.
patent: 4746659 (1988-05-01), DeGraw et al.
patent: 4889859 (1989-12-01), Taylor et al.
DeGraw, J. I. et al. Synthesis & antitumor activity of 10-alkyl-10-DeAzaminopterins, A convenient synthesis of 10-Deazaminopterin J. Medicinal Chem., 25(10): 1227-1230 (1982).
DeGraw, Kisliuk, Gaumont, Baugh and Nair J. Med. Chem 17,552.1974.
Nair, J. Org. Chem. 50,1879,1985.
Thongprasert, Currie and Budman Canc. Treat. Rep. 71,995,1987.
Nair, Nanavati, Kumar, Gaumont and Kisliuk. J. Med. Chem. 31,181,1988.
Alarcon Graciela
Castaneda Oswaldo
Koopman William J.
Krumdieck Carlos L.
Nair Madhavan G.
Hollinden Gary E.
Hollrah Glennon H.
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