10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compos

Details 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compos 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compos

1984-06-08

1985-12-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514281, 514821, 546 40, 546 43, A61K 31435, C07D45500, C07D47108

Patent

active

045580529

ABSTRACT:
10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated N.sub.b -quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.

REFERENCES:
Volkner et al., "Uber die Herzwirkung von Ajmalinderivaten bei Kaninchen, . . . ", (1962) and English translation.
Petter et al., "Zur Antifibrillaren Herzwirkung von Ajmalin, . . . ", (1962) and English translation.
Anet, et al., J. Chem. Soc., 1954, pp. 1242-1260 (1954).
Petter, et al., Arch. Exptl. Pathol. Pharmakol., 243, pp. 519-527 (1962).
Bonati, et al., Chemical Abstracts, vol. 88, 23231g (1978).
Siddiqui, et al., Chemical Abstracts, vol. 54, 25588c (1960).
Ahmad, et al., Chemical Abstracts, vol. 79, 53652b (1973).
Robinson, Chemical Abstracts, vol. 50, 13957g (1956).

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