10-(Bis-pyrrolinyl) phenoxazines

Details 10-(Bis-pyrrolinyl) phenoxazines 10-(Bis-pyrrolinyl) phenoxazines

1978-01-13

1978-09-19

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544102, A61K 31535, C07D41300

Patent

active

041155718

ABSTRACT:
Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolinyl-2-yl)-2-pyrrolin-2-yl]-phe nothiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

REFERENCES:
patent: 2485212 (1959-10-01), Miescher et al.
patent: 3305547 (1967-02-01), Stach et al.
patent: 3498986 (1970-03-01), Meisels et al.
patent: 3719671 (1973-03-01), Wu et al.
patent: 3770727 (1963-11-01), Brack
patent: 3888852 (1975-06-01), Wu et al.
patent: 3946004 (1976-03-01), Wu et al.
patent: 4077959 (1978-03-01), Wu et al.
Moskovkina et al., Chem. Abstracts, abst. No. 14649n (1970).

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