10-(Bis-pyrrolinyl)acridans

Details 10-(Bis-pyrrolinyl)acridans 10-(Bis-pyrrolinyl)acridans

1975-12-15

1978-03-07

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21914

Patent

active

040779599

ABSTRACT:
Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2yl]phenoth iazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

REFERENCES:
patent: 2770727 (1973-11-01), Brack
patent: 3498986 (1970-03-01), Meisels et al.
patent: 3962252 (1976-06-01), Wu et al.
Moskoukina et al., Chemical Abstracts, vol. 73, 14,649n, (1970).

Affiliated with

Also associated with

Rating

10-(Bis-pyrrolinyl)acridans does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 10-(Bis-pyrrolinyl)acridans, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 10-(Bis-pyrrolinyl)acridans will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2020036