Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-04-27
1982-03-30
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424243, 26023955C, 26023955R, 2603973, 2603974, A61K 3156, C07J 100
Patent
active
043224164
ABSTRACT:
Aromatase inhibitors are provided having the formula ##STR1## wherein represents a single or double bond; R is hydrogen or C.sub.1-4 alkyl; R.sup.1 is methyl or ethyl; R.sup.2 is (H) (OR.sup.8) or .dbd.O; R.sup.3 is H or C.sub.1-3 alkyl; R.sup.4 is H or OR.sup.8 ; R.sup.5 is H, C.sub.1-3 alkyl or, when the 5,6-bond is saturated, R.sup.5 is divalent .dbd.O; R.sup.6 and R.sup.7 are each H or C.sub.1-3 alkyl; and R.sup.8 is H or C.sub.2-4 alkanoyl. Intermediates useful in preparing the foregoing aromatase inhibitors, and methods of using the aromatase inhibitors of the invention are also provided.
REFERENCES:
patent: 3127427 (1964-03-01), Boller et al.
patent: 3218316 (1965-11-01), Edwards
Tetrahedron Letters No. 23 (1979), pp. 2105-2108, relied on Article by D. F. Covey et al.
J. Biol. Chem., No. 256 (1981), p. 1076, Article by D. F. Covey et al.
Johnston J. O'Neal
Metcalf Brian W.
Kolano John J.
McDonald Raymond A.
Merrell Dow Pharmaceuticals Inc.
Roberts Elbert L.
Street Gary D.
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