10-Alkyl-10-deazaminopterins

Details 10-Alkyl-10-deazaminopterins 10-Alkyl-10-deazaminopterins

1981-02-10

1983-01-18

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

424251, C07D47508

Patent

active

043693199

ABSTRACT:
A process and composition are provided employing 10-deazaminopterin and 10-alkyl derivatives thereof for the treatment of leukemia, as well as other tumor systems including those of ascitic character, and also a process for preparing 10-deazaminopterin compounds.

REFERENCES:
DeGraw et al., Journal of Medicinal Chemistry, 1974, vol. 17, No. 5, pp. 552 and 553.

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