Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-26
2006-12-26
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S101000
Reexamination Certificate
active
07153851
ABSTRACT:
A compound as represented by the general formula (I) shown below exhibits high antibacterial activity against gram-positive bacteria, in particular, such drug-resistant bacteria as mRNA, PRSP and VRE:wherein R1 is a methyl group, a fluoromethyl group, a methoxymethyl group, an acetoxymethyl group, a hydroxymethyl group or a methylene; R2 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, or a pharmaceutically acceptable cation and an ester of a prodrug; R3 is a hydrogen atom or a halogen atom; R4 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, a fluoromethyl group, a trifluoromethyl group or a fluorine atom; and R5 is a hydrogen atom or a fluorine atom, with exceptions where R1 is a methyl group, R4 and R5 are at the same time a hydrogen atom, and R3 is a fluorine atom.
REFERENCES:
patent: 900793 (1999-03-01), None
patent: 62-155282 (1987-07-01), None
patent: 10-287669 (1998-10-01), None
Kawakami et al. (Antimicrobial Agents And Chemotherapy, Aug. 2000, p. 2126-2129).
Katsuhiro Kawakami, et al., “Antimycobacterial activities of novel levofloxacin analogues”, Antimicrobial Agents and Chemotherapy, vol. 44, No. 8, pp. 2126-2129, 2000.
Asahina Yoshikazu
Takei Masaya
Habte Kahsay
Kyorin Pharmaceutical Co. Ltd.
Wenderoth , Lind & Ponack, L.L.P.
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