10,11-methanodibenzosuberane derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 31495

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active

060873655

ABSTRACT:
10,11-Methanodibenzosuberane derivatives, i.e., the compounds of Formula I: ##STR1## wherein: A is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHR.sup.a --CH.sub.2 --, or --CH.sub.2 --CHR.sup.a --CHR.sup.b --CH.sub.2 --, where one of R.sup.a or R.sup.b is H, OH, or lower acyloxy, and the other is H;
R.sup.1 is H, F, Cl or Br;
R.sup.2 is H, F, Cl or Br; and
R.sup.3 is heteroaryl or phenyl optionally substuted with F, Cl, Br, CF.sub.3, CN, NO, or OCHF.sub.2 ;
and the pharmaceutically acceptable salts thereof, are useful chemosensitizing agents, e.g., for cancer chemotherapy, particularly for treating multidrug resistance.

REFERENCES:
patent: 3133925 (1964-05-01), Cusic
patent: 4015003 (1977-03-01), Uyeda
patent: 4123527 (1978-10-01), Mellion et al.
patent: 4749703 (1988-06-01), Uno et al.
patent: 4918073 (1990-04-01), Ruger et al.
patent: 5112817 (1992-05-01), Fukazawa et al.

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