10,11-dihydro-dibenzo-[b,f][1,4]-thiazepin derivatives

Details 10,11-dihydro-dibenzo-[b,f][1,4]-thiazepin derivatives 10,11-dihydro-dibenzo-[b,f][1,4]-thiazepin derivatives

1986-11-10

1988-03-01

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540547, A61K 3155, C07D28116

Patent

active

047287357

ABSTRACT:
Compounds of the Formula I: ##STR1## are inhibitors of the mammalian 5-lipoxygenase enzyme system of the arachidonic acid cascade. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation and are useful as cytoprotective agents.

REFERENCES:
patent: 3539573 (1970-11-01), Schmutz et al.
patent: 3860606 (1975-01-01), Van Der Burg
patent: 4263207 (1981-04-01), Rokach
Schmutz et al, C.A., vol. 69, 1968 69: 36193(d) p. 3386.
Schmutz et al, C.A., vol. 69, 1968 69: 36195(f) p. 3386.
Shen et al, The Development of Antiasthmatic Drug Part III, ed, Butterworth Publishers, Kent, England pp. 315-336.

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