10,11-dihydro-5-alkyl-12-substituted-10,5-(iminomethano)-5H-d ib

Details 10,11-dihydro-5-alkyl-12-substituted-10,5-(iminomethano)-5H-d ib 10,11-dihydro-5-alkyl-12-substituted-10,5-(iminomethano)-5H-d ib

1989-10-10

1990-07-10

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D48708

Patent

active

049407899

ABSTRACT:
This invention involves novel neuroprotectant agents of the formula: ##STR1## in which R.sup.1 and R.sup.3 are, independently, hydrogen, alkyl, alkoxy, hydroxy, cyano, nitro, halo, trifluoromethyl, amino, alkylamino or dialkylamino; R.sup.2 is alkyl; R.sup.4 is alkyl, phenyl or benzyl; n is 0 or 1; m is one of the integers 0,1,2,3,4,5 or 6; and X is alkyl, alkylamino, dialkylamino, alkanoyl or substituted or unsubstituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolyl, morpholinyl, furyl thienyl, pyrrolyl, tetrahydrofuryl, tetrahydrothienyl, pyrrolidinyl, piperidinyl, piperazinyl or perhydropyridminyl, in which the subsitutent is alkyl, alkoxy, halo, trifluoromethyl, cyano, nitro or hydroxy; or a pharmaceutically acceptable salt thereof; and their use in control of degenerative CNS disease states.

REFERENCES:
patent: 3509158 (1970-04-01), Dobson et al.
patent: 3597433 (1971-08-01), Dobson et al.
Brooks et al., J. Chem. Soc., Perkin I, 2588-2591 (1973).
Takayama et al., Chemistry Lett., 865-866 (1978).

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