10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones

Details 10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones 10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones

1981-09-28

1983-05-24

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602393T, 424200, 424274, 548414, 548492, C07D51304

Patent

active

043851800

ABSTRACT:
Disclosed herein are N-(3-mercapto-2-alkyl-1-oxopropyl)-2,5-dihydro-1H-indole-2-carboxylic acids and derivatives thereof which act as inhibitors of angiotensin converting enzyme and as anti-hypertensive agents. Derivatives include those in which the 5-mercapto group is substituted with phosphate derivatives or is replaced by a variously substituted amino group. The compounds of the invention (excluding disclosed intermediates) have the general formula: ##STR1## wherein: n is 1 or 0;

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