10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phe nyl-10H-ph

Details 10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phe nyl-10H-ph 10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phe nyl-10H-ph

1987-07-27

1988-10-11

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

546 23, 548112, 549222, 568 12, C07F 902

Patent

active

047772905

ABSTRACT:
Novel 10,10-Dihydro-10-[(substituted carbonyl)imino]-10-phenyl-10H-phenoxaphines of the formula: ##STR1## wherein A is selected from the group consisting of hydrogen and COOR.sub.1, where, when A is hydrogen the compound is in the form of a water soluble salt HnX, where n is an integer 1 or 2 and X is selected from the group consisting of sulfate, trefluoroacetate, bromide and chloride and R.sub.1 is selected from the group consisting of straight or branched chain alkyl(C.sub.1 -C.sub.4), alkenyl(C.sub.2 -C.sub.4), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.6), cycloalkyl(C.sub.3 -C.sub.6)methyl, benzyl, pyridylmethyl and tetrahydro-3-furanyl; methods for using these compounds for effecting diuresis, treating hypertension and edema and lowering plasma renin activity in mammals; pharmaceutical compositions of matter containing these compounds and processes for their preparation.

REFERENCES:
patent: 3576863 (1971-04-01), Strycker

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