10-(1,2-Propadienyl) steroids as irreversible aromatase inhibito

Details 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibito 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibito

1980-06-27

1981-09-15

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424241, 424243, 26023955R, 26023955C, 2603973, 2603975, 2603974, A61K 3156, A61K 3158

Patent

active

042897629

ABSTRACT:
Irreversible aromatase inhibitors are provided having the formulae ##STR1## wherein represents a single or a double bond; R.sup.1 is CH.sub.3 or C.sub.2 H.sub.5 ; R.sup.2 is (H) (OR.sup.8) or O; R.sup.3 is H or C.sub.1-3 alkyl; R.sup.4 is H or OR.sup.8 ; R.sup.5 is H.sub.2, O or (H) (C.sub.1-3 alkyl); R.sup.6 and R.sup.7 are each independently H or C.sub.1-3 alkyl; and R.sup.8 is H or C.sub.1-4 alkanoyl. Intermediates useful in preparing the foregoing aromatase inhibitors, methods of using them and a pharmaceutical composition containing them are also provided.

REFERENCES:
patent: 3939264 (1976-02-01), Lachnit-Fixson
patent: 4052421 (1977-10-01), Biollaz et al.

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