Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-06-21
2010-12-28
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S004100, C536S018400, C536S018500, C514S025000, C549S477000
Reexamination Certificate
active
07858761
ABSTRACT:
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple procedure such as recrystallization, and therefore, it can be advantageously used as an intermediate in the preparation of gemcitabine in a large scale. Further, the 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) can be prepared with high stereoselectivity using the compound of formula (V) as an intermediate.
REFERENCES:
patent: 4526988 (1985-07-01), Hertel
patent: 5252756 (1993-10-01), Chou et al.
patent: 5401861 (1995-03-01), Chou et al.
patent: 5453499 (1995-09-01), Chou et al.
patent: 5744597 (1998-04-01), Chou et al.
patent: 5945547 (1999-08-01), Chou et al.
patent: 0 450 585 (1991-10-01), None
patent: 0 576 231 (1993-12-01), None
patent: 5-97885 (1993-04-01), None
patent: 6-056863 (1994-03-01), None
patent: 2003-055364 (2002-02-01), None
Corey, E.J., et al., “New Reagents for Stereoselective Carbonyl Reduction. An Improved Synthetic Route to the Primary Prostaglandins,” J. Am Chem Society, 93:6, Mar. 24, 1971, pp. 1491-1493.
Canadian Intellectual Property, Office Action dated Nov. 24, 2008.
Japanese Office Action from counterpart application No. 2007-523465 dated Aug. 31, 2010.
Bang Hyo-Jeong
Chang Young-Kil
Kim Han Kyong
Lee Gwan Sun
Lee Jaeheon
Hanmi Pharm. Co., Ltd
Henry Michael C
Jiang Shaojia Anna
Sughrue & Mion, PLLC
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