1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S004100, C536S018400, C536S018500, C514S025000, C549S477000

Reexamination Certificate

active

07858761

ABSTRACT:
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple procedure such as recrystallization, and therefore, it can be advantageously used as an intermediate in the preparation of gemcitabine in a large scale. Further, the 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) can be prepared with high stereoselectivity using the compound of formula (V) as an intermediate.

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Canadian Intellectual Property, Office Action dated Nov. 24, 2008.
Japanese Office Action from counterpart application No. 2007-523465 dated Aug. 31, 2010.

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