1-Triarylalkyl-4-phenyl-4-piperidine carboxylic acids and deriva

Details 1-Triarylalkyl-4-phenyl-4-piperidine carboxylic acids and deriva 1-Triarylalkyl-4-phenyl-4-piperidine carboxylic acids and deriva

1976-11-15

1978-01-03

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029372, 26029381, 424267, 424263, C07D40106, C07D21164

Patent

active

040666549

ABSTRACT:
The present invention encompasses compounds of the formula ##STR1## wherein the Alk is straight or branched chain alkylene containing 2-4 carbon atoms; Ar and Ar' are phenyl, Alkyl substituted phenyl wherein the alkyl contains from 1-4 carbon atoms or halo substituted phenyl; Ar" is phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, halo substituted phenyl or pyridyl; X is hydrogen, halogen, trifluoromethyl or alkyl having from 1-4 carbon atoms; R is hydrogen, alkyl having from 1-7 carbon atoms, alkenyl having 3-7 carbon atoms, Ar" as herein before defined, or a cation selected from the group consisting of sodium, potassium, ammonium or calcium/2. Compounds of the present invention are potent antidiarrheal agents with little, if any, central nervous system activity.

REFERENCES:
Patai, "J. Chem. Soc.", pp. 716-723, (1962).
Martensson et al., "Acta Chem. Scand", vol. 19, No. 3, pp. 711-722, (1965).
Bochow, "Chem. Ber.", pp. 3475-3482, (1975), vol. 108.

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