1-thiocarbamylmethylpyrrolidine-2-thione, process for preparing

Details 1-thiocarbamylmethylpyrrolidine-2-thione, process for preparing 1-thiocarbamylmethylpyrrolidine-2-thione, process for preparing

1989-04-05

1989-10-24

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20724

Patent

active

048763608

ABSTRACT:
A novel compound, namely, 1-thiocarbamylmethylpyrrolidine-2-thione has the following formula: ##STR1## A process for preparing said compound comprises reacting a derivative of pyrrolidone-2 of the general formula: ##STR2## wherein R is nitrile or carbamoyl, with phosphorus pentasulphide in an inert non-polar solvent at a temperature above room temperature, followed by treatment of the resulting precipitate with water upon boiling and isolation of the desired product.
The compound according to the present invention exhibits antihypoxic and nootropic activity.

REFERENCES:
Methoden der Organischen Chemie (Houben Weyl), vol. XI/2, 1958, (Georg Thieme Verlag, Stuttgart), p. 575.

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