1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antit

Details 1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antit 1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antit

1976-03-08

1977-08-02

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424322, 424323, 260554, C07C12715, C07C13306, A61K 3117, A61K 31175

Patent

active

040395782

ABSTRACT:
Novel water-soluble nitrosourea derivatives of the formula ##STR1## WHEREIN R represents a 2', 3', 4', 5'-tetrahydroxycyclopentyl group exhibit high effectiveness in various animal tumor systems.

REFERENCES:
patent: 3859277 (1975-01-01), Murakami et al.
Wheeler et al., Cancer Research, 34, 194-200, Jan. 1974.
Johnston et al., J. Med. Chem. 9:892-911 (1966) and J. Med. Chem. 14 : 600-614 (1971).
Serrou et al., C. R. Hebd. Seances Acad. Sci., Ser. D 1974, 279(8), 703-706.
Montero et al., C. R. Hebd. Seances Acad. Sci., Ser. C 1974, 279(18), 809-811.
Anderson et al., Cancer Research, 35:761-765 (1975).
Johnston et al., J. Med. Chem. 18(1):104-106 (1975).
Suami et al., Bull. Chem. Soc. Japan, 46:2562-2564 (1973).

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