1-Tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxaxolines

Details 1-Tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxaxolines 1-Tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxaxolines

1974-02-25

1976-01-06

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424248, C07D26354

Patent

active

039311724

ABSTRACT:
The invention discloses 1-tertiary-butyl-3-morpholino-3-phenyl-2,1-benzisoxazolines having pharmacological activity in animals and useful, for example, as hypolipidemic agents. The compounds may be prepared by reacting a 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt, e.g., 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium tetrafluoroborate with morpholine. The 1-tertiary-butyl-3-phenyl-2,1-benzisoxazolium quaternary salt may be prepared by reaction of a corresponding 3-phenyl-2,1-benzisoxazole with tertiary-butanol in the presence of a strong inorganic acid.

REFERENCES:
nakagawa et al., Chem. Pharm. Bull. 20(10), 2209-2214 (1972).

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