1-t-butyl ergolines useful in the treatment of cerebral insuffic

Details 1-t-butyl ergolines useful in the treatment of cerebral insuffic 1-t-butyl ergolines useful in the treatment of cerebral insuffic

1987-06-23

1989-06-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, A61K 3148, C07D45702

Patent

active

048430730

ABSTRACT:
t-Alkyl ergoline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 =H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts.
A process for the preparation of these derivatives from lysergol and a t-alkyl alcohol is also described, as are pharmaceutical compositions containing them.

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