Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1982-01-26
1984-03-27
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
250303, 128 11, 128659, 127 30, 536 11, A61K 4902
Patent
active
044394144
ABSTRACT:
The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
REFERENCES:
Shiue, C-Y., et al., Carbohydrate Research, vol. 74, pp. 1-4 (1979).
Raichle et al., Science, vol. 199, pp. 986-987 (1978).
Wolf et al., Radiopharmaceuticals & Labelled Compounds, vol. 1, pp. 345-381 (1973).
Heindel, N. P. et al., Chemistry of Radiopharmaceuticals, pp. 109-122, Mason Publishing, N.Y. (1978).
Depresseux, J. C. et al., European Neurology, vol. 20, pp. 270-272 (1981).
Goulding, R. W. et al., Internat. J. Applied Radiation & Isotopes, vol. 24, pp. 7-12 (1973).
Lifton, J. F. et al., Radiation Research, vol. 45, pp. 35-40 (1971).
Shiue Chyng-Yann
Wolf Alfred P.
Bogosian Margaret C.
Gottlieb Paul A.
Moskowitz M.
Padgett Benjamin R.
The United States of America as represented by the United States
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