1-sulfo-2-oxozetidine derivatives and their product ion

Details 1-sulfo-2-oxozetidine derivatives and their product ion 1-sulfo-2-oxozetidine derivatives and their product ion

1981-12-03

1989-04-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540355, A61K 31395, A61K 31425, C07D20508, C07D41712

Patent

active

048227889

ABSTRACT:
Disclosed are compounds of the general formula: ##STR1## wherein R.sub.1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R.sup.4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R.sub.4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula ##STR2## wherein R.sub.5 is an organic residue and n is 0, 1 or 2, and pharmeceutically acceptable salts and esters thereof.
The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.

REFERENCES:
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
patent: 4501697 (1985-02-01), Kronenthal
patent: 4502994 (1985-03-01), Wei et al.
Sykes et al., Chem. Abs. 95, 217370s (1981).
Matsuo et al., Chem. Abs. 95, 97566m (1981).
Imada et al., Nature, vol. 289, pp. 590-591 (1981).
Sykes et al., Nature, vol. 291, pp. 489-491 (1981).
12th International Congress of Chemotherapy, Florence, Italy, Jul. 19-24, 1981, pp. 55-56.
Sykes et al., Journal of Antimicrobial Chemotherapy, (1981) 8, Suppl. E 1-16.

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