1-sulfo-2-oxoazetidine derivatives and their production

Details 1-sulfo-2-oxoazetidine derivatives and their production 1-sulfo-2-oxoazetidine derivatives and their production

1983-05-31

1988-11-01

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07D41712, A61K 31395, A61K 31425

Patent

active

047821477

ABSTRACT:
Disclosed are compounds of the general formula: ##STR1## wherein R.sub.1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R.sup.4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R.sub.4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula ##STR2## wherein R.sub.5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof.
The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.

REFERENCES:
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
IUPAC Organic Nomenclature Rule, "IUPAC Information Bulletin, Appendix 31, Aug. 1973", p. C-87.1.
Imada et al., Nature, vol. 289, pp. 590-591 (1981).
Sykes et al., Nature, vol. 291, pp. 489-491 (1981).
12th International Congress of Chemotherapy, Florence, Italy 19-24 Jul., 1981, pp. 55-56.
Sykes et al., Journal of Antimicrobial Chemotherapy, (1981) 8, Suppl. E 1-16.
Sykes et al., Chemical Abstracts, 95, 21737OS (1981).
Matsuo et al., Chemical Abstracts, 95, 97566M (1981).

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