1-Sulfo-2-oxoazetidine derivatives and their production

Details 1-Sulfo-2-oxoazetidine derivatives and their production 1-Sulfo-2-oxoazetidine derivatives and their production

1981-12-03

1985-10-29

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544359, 544360, 260239A, 544362, 544363, 2602454, 544364, 544365, 2603303, 544366, 544367, 2603309, 544369, 544370, 544 90, 544371, 544372, 544238, 544374, 544377, 544229, 544379, 544405, 544279, 544406, 544407, 544295, 544408, 544409, 544296, 546 14, 546114, 544298, 546122, 546123, 544300, 546153, 546155, 544301, 546156, 546157, 544310, 546159, 546162, 544311, 546187, 546193, 544316, 546194, 546197, 544317, 546208, 546209, 544319, 546210, 546211, 544320, 546256, 546261, 544321, 546263, 546264, 544322, 5462

Patent

active

045501050

ABSTRACT:
Disclosed are compounds of the general formula: ##STR1## wherein R.sub.1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R.sup.4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R.sub.4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula --OR.sub.5, ##STR2## or --S--S--R.sub.5 wherein R.sub.5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof.
The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.

REFERENCES:
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
Imada et al., Nature, vol. 289, pp. 590-591 (1981).
Sykes et al., Nature, vol. 291, pp. 489-491 (1981).
12th International Congress of Chemotherapy, Florence, Italy, Jul. 19-24, 1981, pp. 55-56.
Sykes et al., Journal of Antimicrobial Chemotherapy, (1981) 8, Suppl. E 1-16.
Sykes et al., Chemical Abstracts, 95, 217370S (1981).
Matsuo et al., Chemical Abstracts, 95, 97566M (1981).

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