1-sulfo-2-oxoazetidine derivatives and their production

Details 1-sulfo-2-oxoazetidine derivatives and their production 1-sulfo-2-oxoazetidine derivatives and their production

1982-08-05

1987-06-23

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20508, C07D41712, A61K 31425, A61K 31395

Patent

active

046753974

ABSTRACT:
Disclosed are compounds of the general formula: ##STR1## wherein R.sub.1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R.sup.4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R.sub.4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula --OR.sub.5, ##STR2## or --S--S--R.sub.5 wherein R.sub.5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof.
The compounds have antimicrobial and/or .beta.-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.

REFERENCES:
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4225586 (1980-09-01), Imada et al.
patent: 4229436 (1980-10-01), Imada et al.
Imada et al., Nature, vol. 289, pp. 590-591, (1981).
Sykes et al., Nature, vol. 291, pp. 489-491, (1981).
12th International Congress of Chemotherapy, Florence, Italy, Jul. 19-24 1981, pp. 55-56.
Sykes et al., Journal of Antimicrobial Chemotherapy, (1981) 8, Suppl. E 1-16.
Sykes et al., Chemical Abstracts, 95, 217370S (1981).
Matsuo et al., Chemical Abstracts, 95, 97566M (1981).

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