1'-Substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-triones

Details 1'-Substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-triones 1'-Substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-triones

1982-05-11

1984-10-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548410, A61K 3140, C07D20996

Patent

active

044788479

ABSTRACT:
The invention provides a pharmaceutical composition comprising an aldose reductase inhibitory 1'-substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-trione of the formula: ##STR1## wherein Ra is (2-7C)alkyl or (3-7C)alkenyl, naphthylmethyl or cinnamyl optionally bearing one or two halogeno nuclear substituents, or Ra is benzyl optionally bearing one or two substituents and benzene ring A optionally bears one or two substituents, trifluoromethyl and nitro; or a salt thereof with a base affording a pharmaceutically acceptable cation; or a non-toxic, biodegradable precursor thereof; together with a pharmaceutically acceptable diluent or carrier. The invention also provides novel compounds of formula I and processes for their manufacture.
The compositions are of application in the treatment or prophylaxis of the side effects of diabetes or galactosemia.

REFERENCES:
patent: 4177230 (1978-09-01), Sarges
patent: 4307108 (1981-12-01), Belletire
H. Schaefer, Archiv. der Pharmazie, (Weinheim), 1970, 303, 183-191; Chem. Abstracts, 1970, 73, 3739.

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