1'-Substituted-spiro[oxazolidine-5-3'-indoline]-2,2', 4-trione d

Details 1'-Substituted-spiro[oxazolidine-5-3'-indoline]-2,2', 4-trione d 1'-Substituted-spiro[oxazolidine-5-3'-indoline]-2,2', 4-trione d

1983-05-06

1985-10-01

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548216, 549486, C07D49810, C07D26344, A61K 3142

Patent

active

045446628

ABSTRACT:
The invention provides novel spiro[oxazolidine-5,3'-indoline]-2,2',4-triones of formula I bearing substituted benzyl or cinnamyl on the indoline nitrogen, together with salts and non-toxic, biodegradable precursors thereof. The compounds are potent inhibitors of the enzyme aldose reductase and are useful in treating or preventing certain diabetic complications. The invention also provides pharmaceutical compositions containing, and processes for the manufacture of, the compounds of formula I and their salts and derivatives.

REFERENCES:
patent: 4200642 (1980-04-01), Schnur
patent: 4226875 (1980-10-01), Schnur
Clark-Lewis et al., J. Chem. Soc., 1965, 5551-5556.

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