1-Substituted imidazoles for inhibition of thromboxane synthetas

Details 1-Substituted imidazoles for inhibition of thromboxane synthetas 1-Substituted imidazoles for inhibition of thromboxane synthetas

1979-05-02

1981-03-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2603458R, 2603459R, 548341, A61K 31415, C07D23360

Patent

active

042567572

ABSTRACT:
The imidazole derivatives of the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, the symbol .dbd. represents a double bond that bond is E or Z, or a triple bond, and m and n, which may be the same or different, each represent zero, or an integer of 1 to 10, and non-toxic acid addition salts thereof, and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof are new compounds. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.

REFERENCES:
Burgess et al., Proc. Soc. Exptl. Biol. Med. 1930, vol. 28, pp. 115-11 6 (1930).
Novello et al., Chem. Abst. 1926, vol. 20, p. 3030.
Pailer et al., Monotshefte fur Chemie 1977, vol. 108, pp. 1059-1066.

Affiliated with

Also associated with

Rating

1-Substituted imidazoles for inhibition of thromboxane synthetas does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-Substituted imidazoles for inhibition of thromboxane synthetas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-Substituted imidazoles for inhibition of thromboxane synthetas will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1646169