1-Substituted imidazole derivatives

Details 1-Substituted imidazole derivatives 1-Substituted imidazole derivatives

1979-05-02

1982-10-19

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, 549416, 549419, 549420, C07D23360

Patent

active

043551700

ABSTRACT:
The imidazole derivatives of the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and m and n, which may be the same or different, each represent zero, or an integer of 1 to 10, and non-toxic acid addition salts thereof, and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, are new compounds. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.

REFERENCES:
Sawa et al., Chem Abst. 1975, vol. 82, No. 59035m.
Pailer et al., Monatshefte fur Chemie 1977, vol. 108, pp. 1059-1066.
Hamberg, M. et al., Proc. Nat. Acad. Sci. USA, 72(8), 2994 (1975).
Silver, M. et al., Science, 183, 1085 (1974).

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